Tactical SD

Health News

Emerging Fungal Skin Infections Defy Treatment Norms, Experts Warn

Representation for skin infection caused due to fungus

United States: Experts have voiced concerns regarding novel and emerging fungal skin conditions that exhibit high transmissibility and defy conventional treatment methods, although current infection rates in the United States remain relatively low.

Dr. Avrom Caplan, a dermatologist and research overseer at NYU Grossman School of Medicine, alongside his team, urges healthcare providers to stay vigilant concerning two recent strains of dermatophytes resembling ringworm or jock itch. These are identified as Trichophyton mentagrophytes type VII (TMVII) and Trichophyton indotineae, or T. indotineae.

Their alerts are delineated in a pair of recent publications, as per dermatologytimes.com.

The most recent study, released in JAMA Dermatology, chronicles the maiden instance of TMVII, a sexually transmitted fungal affliction on the rise in Europe, notably affecting men who have sex with men.1

The second study, also published in May in JAMA Dermatology, conducted by Caplan’s team in collaboration with the New York State Department of Health, reveals that cases of T. indoline in the US exhibit resistance to conventional therapies.2

Both TMVII and T. indoline provoke tinea infections like ringworm, jock itch, and athlete’s foot, often misdiagnosed as eczema. Tinea genitals/puborectalis, an infrequent dermatophytosis of genital regions, is correlated with the upsurge of T. indoline, which has seen an escalation in India, influenced by climatic factors, hygiene, and misuse of corticosteroids.

Instances of tinea genitalis in Europe are associated with TMVII, possibly spreading via sexual contact.

The initial report in May details the case of a man in his thirties who contracted TMVII following travels to England, Greece, and California, as reported by dermatologytimes.com.

Confirmation via genetic testing solidified the diagnosis, with the individual reporting multiple male sexual partners during his journeys, none of whom exhibited similar dermatological issues.

Dr. John Zampella, an associate professor in the Ronald O. Perelman Department of Dermatology at NYU and senior author of the study, emphasized in the press release that while TMVII infections pose challenges in treatment and may persist for months, they appear responsive to standard antifungal treatments like terbinafine.

Caplan underscored the importance of physicians directly questioning patients about skin rashes, particularly those who are sexually active.

Visual Representation for fungal infection | Credits: Shutterstock

Although TMVII infections generally respond to standard antifungal therapies, Caplan’s other study highlights the resistance of T. indoline to terbinafine.

According to the report, T. indotineae’s resistance to terbinafine stems from genetic mutations in specific fungal domains, impacting the efficacy of terbinafine binding mechanisms.

Nonetheless, another antifungal agent, itraconazole, remains a potential treatment option, albeit with associated side effects, according to dermatologytimes.com.

Caplan intends to collaborate with fellow experts to gain deeper insights into these emerging fungal infections.

Leave a Reply

Your email address will not be published. Required fields are marked *